Nonetheless, the growth of endometriosis is stimulated by the cyclic ovarian steroids estrogen (E2) and progesterone (P4), and in the absence of these steroids (e.g., after ovariectomy), endometriosis undergoes regression (Shaw, 1992).
Current , an isoxazole derivative of 17a-ethynyltestosterone, has been used for the treatment of endometriosis for the past 15 years.
Pelvic endometriosis and uterine leiomyomas (fibroids) are the two most common disorders in women during reproductive age.
Infertility, pelvic pain, and uterine bleeding are major clinical manifestations.
Ovulatory cycles resumed four to six weeks after completion of treatment.